Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CALCA | P06881 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 6/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21920792 | 1.00 | NPC1 (0.43) | NPC1GSK3BCALCACYP1A2SMN1; SMN2 | |
| SCHEMBL31404120 | 0.79 | PDK2 (0.50) | NPC1GSK3BCYP1A2SMN1; SMN2AKR1B1 | |
| SCHEMBL2268820 | 0.79 | PDK2 (0.50) | NPC1GSK3BCYP1A2SMN1; SMN2AKR1B1 | |
| Hydrochloric Acid SCHEMBL30775696 | 0.77 | PDK2 (0.48) | NPC1GSK3BCYP1A2SMN1; SMN2AKR1B1 | |
| SCHEMBL13004676 | 0.77 | NPC1 (0.46) | NPC1GSK3BCALCACYP1A2SMN1; SMN2 | |
| SCHEMBL24390000 | 0.76 | NPC1 (0.45) | NPC1GSK3BCALCACYP1A2SMN1; SMN2 | |
| SCHEMBL16235885 | 0.74 | CALCA (0.46) | NPC1CALCACYP1A2SMN1; SMN2OTUD7B | |
| SCHEMBL22796660 | 0.73 | NPC1 (0.43) | NPC1GSK3BCALCACYP1A2SMN1; SMN2 | |
| SCHEMBL26040260 | 0.73 | NPC1 (0.43) | NPC1GSK3BCALCACYP1A2SMN1; SMN2 | |
| SCHEMBL1700112 | 0.72 | CALCA (0.49) | CALCAOTUD7BCALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | GENENTECH, INC. (US) | 2025-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | HIPK1, NEK1, HIPK2 | NPC1 1141/4885GSK3B 2071/4885CALCA 3179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.