Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31044666 | 0.78 | RET (0.46) | SMN1; SMN2HSD17B10RETTSHRL3MBTL1 | |
| SCHEMBL29566683 | 0.77 | RET (0.45) | RET | |
| Hydrochloric Acid SCHEMBL28993707 | 0.76 | RET (0.44) | RET | |
| SCHEMBL30725889 | 0.75 | MAOB (0.52) | CYP2C19RET | |
| SCHEMBL30175294 | 0.74 | RET (0.43) | RETALDH1A1L3MBTL1KDM4E | |
| SCHEMBL30175335 | 0.74 | RET (0.37) | SMN1; SMN2RETALDH1A1KDM4EGLA | |
| SCHEMBL25252185 | 0.74 | CDK2 (0.36) | SMN1; SMN2RETALDH1A1KDM4EGLA | |
| SCHEMBL30175370 | 0.74 | CDK2 (0.36) | SMN1; SMN2HSD17B10RETGAAALDH1A1 | |
| SCHEMBL30175367 | 0.73 | RET (0.48) | RET | |
| SCHEMBL30175340 | 0.73 | RET (0.43) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163437-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2025-03-04 | — | — | CN | disclosed |