Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31458919 | 0.78 | MAPT (0.54) | RETSMN1; SMN2TSHRHSD17B10L3MBTL1 | |
| SCHEMBL30725889 | 0.78 | MAOB (0.52) | RETCYP19A1LMNA | |
| SCHEMBL29566683 | 0.77 | RET (0.45) | RET | |
| SCHEMBL25252185 | 0.77 | CDK2 (0.36) | RETSMN1; SMN2CDK2 | |
| SCHEMBL30175370 | 0.77 | CDK2 (0.36) | RETSMN1; SMN2CDK2HSD17B10L3MBTL1 | |
| SCHEMBL31458801 | 0.76 | RET (0.46) | RETCYP19A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL28993707 | 0.76 | RET (0.44) | RET | |
| SCHEMBL30175349 | 0.75 | CYP11B1 (0.41) | RETCDK2L3MBTL1 | |
| SCHEMBL30175296 | 0.75 | RET (0.45) | RET | |
| SCHEMBL30175312 | 0.75 | MAOA (0.35) | RETSMN1; SMN2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |