Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279630 | 0.85 | SMN1; SMN2 (0.42) | ALDH1A1GAAPOLBSMN1; SMN2CYP2C19 | |
| SCHEMBL3995751 | 0.84 | SMN1; SMN2 (0.40) | ALDH1A1GAAPOLBSMN1; SMN2CYP2C19 | |
| SCHEMBL23612824 | 0.81 | SMN1; SMN2 (0.39) | ALDH1A1POLBSMN1; SMN2CYP2C19CYP2C9 | |
| SCHEMBL14097076 | 0.81 | POLB (0.38) | ALDH1A1GAAHPGDPOLBSMN1; SMN2 | |
| SCHEMBL31459112 | 0.80 | GAA (0.44) | ALDH1A1GAAHPGDCYP2C19CYP2C9 | |
| SCHEMBL27258465 | 0.79 | ALDH1A1 (0.44) | ALDH1A1GAAHPGDPOLBSMN1; SMN2 | |
| SCHEMBL14487412 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAAHPGDCYP2C19HDAC6 | |
| SCHEMBL20488115 | 0.77 | SMN1; SMN2 (0.47) | ALDH1A1GAAPOLBSMN1; SMN2CYP2C19 | |
| SCHEMBL3999420 | 0.77 | KMT2A (0.38) | GAAPOLBSMN1; SMN2CYP2C19CYP2C9 | |
| SCHEMBL19994230 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1GAAHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096660-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096654-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096662-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096658-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096653-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096657-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |