Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 6/20 | 0.56 |
| ▸ | ESRRG | P62508 | 4/20 | 0.56 |
| ▸ | ESRRB | O95718 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24688920 | 0.88 | MAPT (0.78) | KDM4EMAPTALDH1A1PKMESR1 | |
| SCHEMBL7041242 | 0.82 | MAPT (0.68) | KDM4EMAPTALDH1A1PKMTDP1 | |
| SCHEMBL20074141 | 0.82 | KDM4E (0.69) | KDM4EMAPTALDH1A1PKMESR1 | |
| SCHEMBL81911 | 0.82 | MAPT (0.69) | KDM4EMAPTALDH1A1PKMESRRG | |
| Bromide SCHEMBL11208376 | 0.80 | KDM4E (0.67) | KDM4EMAPTALDH1A1PKMESR1 | |
| SCHEMBL24688923 | 0.80 | ESRRG (0.65) | KDM4EMAPTALDH1A1PKMESR1 | |
| SCHEMBL2543118 | 0.80 | KDM4E (0.67) | KDM4EMAPTALDH1A1PKMESR1 | |
| SCHEMBL12582119 | 0.80 | MAPT (0.67) | KDM4EMAPTALDH1A1PKMTDP1 | |
| SCHEMBL10169302 | 0.80 | MAPT (0.67) | KDM4EMAPTALDH1A1PKMESRRG | |
| SCHEMBL13898896 | 0.80 | KDM4E (0.67) | KDM4EMAPTALDH1A1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334481-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-05-10 | — | — | US | disclosed |
| US-20130196989-A1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-01 | — | — | US | disclosed |
| EP-1682150-B1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | SCRIPPS RESEARCH INST (US) | 2012-12-26 | — | — | EP | disclosed |
| US-8309555-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-11-13 | — | — | US | disclosed |
| US-8309555-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-11-13 | — | — | US | disclosed |
| US-7951592-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951592-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-05-31 | — | — | US | disclosed |
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
| US-20100022533-A1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
| US-20100022533-A1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
| US-4788190-A | 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds | SCHERING CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0278105-A1 | 2,4,4-Tri- and 2,2,4,4-tetra-substituted-1,3-dioxolane | SCHERING CORPORATION (US) | 1988-08-17 | — | — | EP | disclosed |
| WO-1988005048-A1 | 2,4,4-TRI- AND 2,2,4,4-TETRA SUBSTITUTED-1,3-DIOXOLANE COMPOUNDS | SCHERING CORPORATION (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0072623-B1 | IMIDAZOLE ANTIFUNGAL AGENTS | Pfizer Limited (GB) | 1985-06-05 | — | — | EP | disclosed |
| US-4435399-A | 2-Aryl-1-(imidazol-1-yl)-8-(4-piperazin-1-ylphenoxy) octan-2-ol antifungal agents | PFIZER INC. (US) | 1984-03-06 | — | — | US | disclosed |
| EP-0072623-A1 | Imidazole antifungal agents | Pfizer Limited (GB) | 1983-02-23 | — | — | EP | disclosed |
| US-4358449-A | 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles and compositions | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-11-09 | — | — | US | disclosed |
| US-4335125-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-06-15 | — | — | US | disclosed |
| US-4223036-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-09-16 | — | — | US | disclosed |
| US-4144346-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196989-A1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | ALPG, PAX3, RARG | KDM4E 1032/4885MAPT 4677/4885ALDH1A1 64/4885 |
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | PIK3CA, PIK3CD, PIK3CB | KDM4E 3910/4885MAPT 4111/4885ALDH1A1 4446/4885 |
| US-20100022533-A1 | COMPOSITIONS AND METHODS FOR INDUCING CELL DEDIFFERENTIATION | ALPG, PAX3, RARG | KDM4E 1032/4885MAPT 4677/4885ALDH1A1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.