PAX3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL31661274	0.51	4/20
SCHEMBL31661281	0.52	3/20
SCHEMBL25324519	0.46	2/20
SCHEMBL11703118	0.50	1/20
SCHEMBL11703130	0.50	1/20
SCHEMBL17283462	0.47	1/20
SCHEMBL9728432	0.46	1/20
SCHEMBL1425017	0.46	1/20
SCHEMBL4405834	0.46	1/20
SCHEMBL9728547	0.46	1/20
SCHEMBL28251697	0.46	1/20
SCHEMBL9154861	0.46	1/20
SCHEMBL13872774	0.46	1/20
SCHEMBL29283546	0.46	1/20
SCHEMBL12375884	0.45	1/20
SCHEMBL26857602	0.45	1/20
SCHEMBL11102577	0.44	1/20
SCHEMBL5385642	0.44	1/20
SCHEMBL18104410	0.43	1/20
SCHEMBL7393964	0.43	1/20

Clinical trials — most relevant to PAX3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma	PHASE3	ACTIVE_NOT_RECRUITING
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma	PHASE1/PHASE2	RECRUITING
Evolutionary Therapy for Rhabdomyosarcoma	PHASE2	ACTIVE_NOT_RECRUITING
Systemic Therapy and Chemoradiation in Advanced Localised Pancreatic Cancer - 2	PHASE1/PHASE2	COMPLETED
FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma	PHASE1	RECRUITING
Biomarkers in Patients With Advanced Rhabdomyosarcoma	nan	COMPLETED
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
Cervical Cytology DNA Methylation for Cervical Cancer Screening	nan	NOT_YET_RECRUITING
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Studying Mechanisms of Radiation Therapy Resistance in Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
The Role of TBX3 in Human ES Cell Differentiation	nan	WITHDRAWN
Clinico-biological Study/Characterization of Rhabdomyosarcoma in Adolescents and Young Adults, 15-25-year-old Patients	nan	UNKNOWN
The Role of CSF in Chiari II Brain Malformation	nan	NOT_YET_RECRUITING
B3 for NMD: Bench to Bedside and Back	nan	ENROLLING_BY_INVITATION
Chordoma Family Study	nan	COMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
Changes of microRNA Expression in Obstructive and Neurogenic Bladder Dysfunction	nan	COMPLETED
Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families	nan	COMPLETED
Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique	nan	COMPLETED
Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors	nan	COMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study	nan	COMPLETED
DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma	nan	COMPLETED
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
Congenital Aniridia Patient Questionnaire	nan	RECRUITING
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Role of HIF-1α in Skeletal Muscle Aging	nan	UNKNOWN
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PAX3 binder may also engage these)

Protein	Name	Similarity
P24610	—	1.000	P24610 →
P47239	—	1.000	P47239 →
Q645N4	—	1.000	Q645N4 →
Q0IH87	—	1.000	Q0IH87 →
P23759	—	1.000	P23759 →
Q1LZF1	—	1.000	Q1LZF1 →
P47238	—	1.000	P47238 →
G5EDS1	—	1.000	G5EDS1 →
P55864	—	1.000	P55864 →
Q812B1	—	1.000	Q812B1 →
P47240	—	1.000	P47240 →
P32114	—	0.999	P32114 →
Q90268	—	0.999	Q90268 →
PAX2	Paired box protein Pax-2	0.999	landscape →
Q9PVY9	—	0.999	Q9PVY9 →
P35680	—	0.999	P35680 →
PAX8	Paired box protein Pax-8	0.999	landscape →
P27889	—	0.999	P27889 →
Q03365	—	0.998	Q03365 →
Q98876	—	0.998	Q98876 →
P31363	—	0.998	P31363 →
O93529	—	0.998	O93529 →
Q91904	—	0.998	Q91904 →
Q22510	—	0.998	Q22510 →
P57682	—	0.998	P57682 →
P47242	—	0.998	P47242 →
O73917	—	0.998	O73917 →
P40645	—	0.997	P40645 →
Q90867	—	0.997	Q90867 →
B7ZQA9	—	0.997	B7ZQA9 →