Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21715256 | 0.86 | HRH3 (0.38) | — | |
| SCHEMBL14737746 | 0.78 | HRH3 (0.38) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL31466461 | 0.78 | — | — | |
| SCHEMBL1952683 | 0.77 | CYP3A4 (0.31) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL1952685 | 0.77 | KDM4E (0.35) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL2957084 | 0.77 | CYP3A4 (0.31) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL2442188 | 0.77 | ALOX15 (0.46) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL738247 | 0.77 | HRH3 (0.33) | CYP3A4CYP2D6HRH1 | |
| SCHEMBL6890281 | 0.77 | S1PR4 (0.35) | CYP3A4CYP2D6HRH1 | |
| Hydrochloric Acid SCHEMBL23886017 | 0.76 | ALOX15 (0.44) | CYP3A4CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049419-A1 | PYRAZOLYL COMPOUNDS AS EMOPAMIL BINDING PROTEIN INHIBITORS | GENZYME CORPORATION (US) | 2025-03-06 | — | — | WO | disclosed |