SCHEMBL31466904

SCHEMBL31466904

COc1ccc(Cl)c(-c2cc3cnc(S(C)(=O)=O)nc3n3cnnc23)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 20/20 0.44
FGFR4 P22455 13/20 0.44
KDR P35968 13/20 0.44
FGFR2 P21802 3/20 0.44
FGFR3 P22607 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31466999 0.91 FGFR1 (0.43) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL21761870 0.90 FGFR1 (0.50) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466893 0.83 FGFR1 (0.38) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31467071 0.82 FGFR1 (0.53) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466843 0.82 FGFR1 (0.43) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466958 0.82 FGFR1 (0.45) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466891 0.82 FGFR1 (0.37) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL23328287 0.82 FGFR1 (0.55) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466908 0.81 FGFR1 (0.33) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466913 0.75 FGFR1 (0.40) FGFR1FGFR4KDRFGFR2FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025064567-A1 TRICYCLIC PHENOLS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2025-03-27 WO disclosed