SCHEMBL31466908

SCHEMBL31466908

Cc1c(O[Si](C)(C)C(C)(C)C)ccc(Cl)c1-c1cc2cnc(S(C)(=O)=O)nc2n2cnnc12

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 14/20 0.33
FGFR4 P22455 9/20 0.33
KDR P35968 9/20 0.33
FGFR2 P21802 1/20 0.33
FGFR3 P22607 1/20 0.33
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
XBP1 P17861 1/20 0.31
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TLR9 Q9NR96 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31466762 0.84 FGFR1 (0.34) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466904 0.81 FGFR1 (0.44) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466893 0.78 FGFR1 (0.38) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466999 0.77 FGFR1 (0.43) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL21761870 0.75 FGFR1 (0.50) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL25395057 0.74 WEE1 (0.41) FGFR1FGFR4FGFR2FGFR3
SCHEMBL30618333 0.74 WEE1 (0.41) FGFR1FGFR4FGFR2FGFR3
SCHEMBL31466843 0.74 FGFR1 (0.43) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL31466891 0.73 FGFR1 (0.37) FGFR1FGFR4KDRFGFR2FGFR3
SCHEMBL23328287 0.69 FGFR1 (0.55) FGFR1FGFR4KDRFGFR2FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025064567-A1 TRICYCLIC PHENOLS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2025-03-27 WO disclosed