Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11816269 | 0.87 | KMT2A (0.49) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL7756386 | 0.80 | KMT2A (0.53) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL1769910 | 0.78 | KMT2A (0.55) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL859237 | 0.77 | NPC1 (0.61) | KMT2AMAPTALDH1A1HTTNPC1 | |
| SCHEMBL1203665 | 0.77 | KMT2A (0.53) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL7082818 | 0.75 | KMT2A (0.51) | KMT2AMAPTCES2CES1ALDH1A1 | |
| SCHEMBL28204092 | 0.75 | NPC1 (0.60) | KMT2AMAPTALDH1A1HTTNPC1 | |
| Hydrochloric Acid SCHEMBL27676954 | 0.75 | NPC1 (0.60) | KMT2AMAPTALDH1A1HTTNPC1 | |
| SCHEMBL7958265 | 0.75 | KMT2A (0.49) | KMT2AMAPTCES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL27592037 | 0.75 | PTPN1 (0.50) | KMT2AMAPTCES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197879-B1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS INC (US) | 2014-01-22 | — | — | EP | claimed |
| EP-2197879-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-06-23 | — | — | EP | claimed |
| US-7687496-B2 | C7-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | claimed |
| WO-2009051580-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | claimed |
| US-20090099224-A1 | C7- substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099224-A1 | C7- substituted camptothecin analogs | ABCB1, ABCC1, ABCG2 | KMT2A 4548/4885MAPT 4513/4885CES2 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.