Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756386 | 0.82 | KMT2A (0.53) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL1769910 | 0.77 | KMT2A (0.55) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL1203665 | 0.75 | KMT2A (0.53) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL3146758 | 0.75 | KMT2A (0.49) | KMT2ACES2CES1SMN1; SMN2NPC1 | |
| SCHEMBL28065903 | 0.73 | KMT2A (0.47) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL31159653 | 0.73 | KMT2A (0.47) | KMT2ACES2CES1SMN1; SMN2PKM | |
| Acetic Acid SCHEMBL27592037 | 0.73 | PTPN1 (0.50) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL28230037 | 0.73 | KMT2A (0.47) | KMT2ACES2CES1SMN1; SMN2PKM | |
| SCHEMBL363937 | 0.72 | — | — | |
| SCHEMBL30698159 | 0.72 | KMT2A (0.69) | KMT2ACES2CES1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310060-B1 | FOR USE AS ANTIPROLIFERATIVE AGENT FOR USE AGAINST CANCER, PSORIASIS, RESTENOSIS, AUTOIMMUNE DISEASE, OR ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2001-10-30 | — | — | US | disclosed |