Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 17/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814478 | 0.86 | CHRM3 (0.66) | CHRM3 | |
| SCHEMBL5285440 | 0.84 | CHRM3 (0.58) | CHRM3 | |
| SCHEMBL3142620 | 0.83 | CHRM3 (0.61) | CHRM3 | |
| SCHEMBL5285760 | 0.82 | CHRM3 (0.62) | CHRM3SLC2A1 | |
| SCHEMBL3138470 | 0.82 | CHRM3 (0.61) | CHRM3 | |
| SCHEMBL3134498 | 0.82 | CHRM3 (0.56) | CHRM3ADRB2 | |
| SCHEMBL3134682 | 0.82 | CHRM3 (0.53) | CHRM3ADRB2 | |
| SCHEMBL5324879 | 0.81 | CHRM3 (0.60) | CHRM3 | |
| SCHEMBL3539951 | 0.80 | CHRM3 (0.53) | CHRM3SLC2A1 | |
| SCHEMBL3128875 | 0.78 | CHRM3 (0.62) | CHRM3SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642355-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-(5-[4-(3-dimethylaminopropoxy)benzylamino]pentylcarbamoyl)ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2010-01-05 | — | — | US | claimed |
| EP-1866284-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006099167-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-09-21 | — | — | WO | claimed |
| EP-1866284-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006099167-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-09-21 | — | — | WO | disclosed |