SCHEMBL31469916

SCHEMBL31469916

Nc1ccc2c(c1)SCC(=O)N2

nearest known ligand 0.64

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.64
MAOA P21397 10/20 0.64
EPHX2 P34913 1/20 0.64
PDE3B Q13370 2/20 0.50
PDE3A Q14432 2/20 0.50
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
HTT P42858 1/20 0.49
CA9 Q16790 1/20 0.47
KIF11 P52732 1/20 0.46
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3599644 1.00 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL395053 0.87 HTT (0.59) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL279937 0.78 EPHX2 (1.00) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL299571 0.78 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL3599640 0.78 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL18307137 0.78 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL5751107 0.78 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL6015836 0.78 MAOB (1.00) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL4219649 0.78 MAOB (0.64) MAOBMAOAEPHX2PDE3BPDE3A
SCHEMBL6754956 0.75 KIF11 (0.68) MAOBMAOAEPHX2PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025076470-A1 SOX10 INHIBITORS AND USES THEREOF THE GENERAL HOSPITAL CORPORATION (US) 2025-04-10 WO disclosed