Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926858 | 0.86 | CYP2A6 (0.62) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL2095967 | 0.79 | CYP2A6 (0.50) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL657643 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL30797819 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL3062248 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL1788007 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL6271346 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL9454459 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL1187043 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 | |
| SCHEMBL1077009 | 0.78 | CYP2A6 (0.53) | CYP2A6KDM4EALDH1A1SMN1; SMN2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1836211-B1 | MACROLIDES | PFIZER PROD INC (US) | 2010-03-03 | — | — | EP | disclosed |
| US-7462600-B2 | Macrolides | PFIZER INC (US) | 2008-12-09 | — | — | US | disclosed |
| CN-101120011-A | Macrolides | PFIZER PROD INC (US) | 2008-02-06 | — | — | CN | disclosed |
| US-20060135447-A1 | Macrolides | CHUPAK LOUIS S | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135447-A1 | Macrolides | LCAT, NOP2, HDAC6 | CYP2A6 426/4885KDM4E 3426/4885ALDH1A1 3275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.