Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thymine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.44 |
| ▸ | DPYD | Q12882 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymine SCHEMBL23794979 | 0.86 | ATAD2 (0.91) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL750450 | 0.85 | ATAD2 (1.00) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL646138 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL31403209 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL6034999 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL23388801 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL2724033 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL4811815 | 0.83 | — | — | |
| Thymine SCHEMBL3500839 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD | |
| Thymine SCHEMBL7043684 | 0.83 | ATAD2 (0.95) | ATAD2GAAALDH1A1LMNADPYD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250114390-A1 | MULTI-ACTIVE TABLET IN THE TREATMENT AND CONTROL OF SEVERE CHRONIC PAIN AND METHOD OF PREPARATION | LABORATORIOS SILANES, S.A. DE C.V. (MX) | 2025-04-10 | — | — | US | disclosed |
| EP-4534077-A1 | COMPOSITION COMPRISING CYANOCOBALAMIN, PYRIDOXINE, THIAMINE, PREGABALIN AND CELECOXIB | Laboratorios Silanes, S.A. de C.V. (MX) | 2025-04-09 | — | — | EP | disclosed |