Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.56 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21917255 | 0.75 | DYRK1A (0.66) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL18746021 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL29814872 | 0.75 | PIM1 (0.59) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL1892610 | 0.75 | PIM1 (0.59) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL1009087 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL2619228 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL245511 | 0.75 | DYRK1A (0.61) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL19443754 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL25421202 | 0.72 | DYRK1A (1.00) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL30461701 | 0.72 | DYRK1A (1.00) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1836211-B1 | MACROLIDES | PFIZER PROD INC (US) | 2010-03-03 | — | — | EP | disclosed |
| CN-101120011-A | Macrolides | PFIZER PROD INC (US) | 2008-02-06 | — | — | CN | disclosed |