Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.66 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.66 |
| ▸ | GSK3B | P49841 | 4/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059758 | 0.83 | GSK3B (0.51) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL29814872 | 0.75 | PIM1 (0.59) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL1892610 | 0.75 | PIM1 (0.59) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL3147182 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL19443754 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL2619228 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL1009087 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL245511 | 0.75 | DYRK1A (0.61) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL18746021 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL25421202 | 0.72 | DYRK1A (1.00) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3801499-B1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20220194933-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. | 2022-06-23 | — | — | US | disclosed |
| US-20220072019-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | DISARM THERAPEUTICS, INC. | 2022-03-10 | — | — | US | disclosed |
| US-20220008405-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS | DISARM THERAPEUTICS, INC. | 2022-01-13 | — | — | US | disclosed |
| WO-2020132045-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEUROPROTECTIVE AGENTS | DISARM THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020081923-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | DISARM THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220072019-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | SARM1, NNMT, NQO1 | DYRK1A 4041/4885NFATC1 3257/4885GSK3B 2056/4885 |
| US-20220194933-A1 | INHIBITORS OF SARM1 | SARM1, SMN1; SMN2, SARNP | DYRK1A 3924/4885NFATC1 2325/4885GSK3B 2202/4885 |
| US-20220008405-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS | SARM1, SMN1; SMN2, SARNP | DYRK1A 3653/4885NFATC1 3072/4885GSK3B 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.