SCHEMBL31471902

SCHEMBL31471902

O=C(Nc1ccc(F)cc1)N1CCN(c2nc(Nc3cc(C4CC4)[nH]n3)c3ccccc3n2)CC1

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PAK4 O96013 3/20 0.65
PAK1 Q13153 3/20 0.65
SRC P12931 1/20 0.55
GSK3B P49841 1/20 0.55
AURKB Q96GD4 1/20 0.55
NTRK1 P04629 2/20 0.55
ULK1 O75385 1/20 0.51
NTRK3 Q16288 1/20 0.50
NTRK2 Q16620 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31471941 0.86 PAK4 (0.71) PAK4PAK1SRCGSK3BAURKB
SCHEMBL31471972 0.81 PAK4 (0.83) PAK4PAK1
SCHEMBL22072524 0.81 PAK4 (0.83) PAK4PAK1
SCHEMBL31471765 0.80 PAK4 (0.81) PAK4PAK1SRCGSK3B
SCHEMBL31471889 0.79 PAK4 (0.74) PAK4PAK1
SCHEMBL31471934 0.78 PAK4 (0.65) PAK4PAK1SRCGSK3BAURKB
SCHEMBL22072089 0.78 PAK4 (0.79) PAK4PAK1ULK1
SCHEMBL22072090 0.77 PAK4 (0.77) PAK4PAK1
SCHEMBL31471773 0.77 ULK1 (0.68) SRCGSK3BAURKBNTRK1ULK1
SCHEMBL31471916 0.77 PAK4 (0.56) PAK4PAK1SRCGSK3BAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025100889-A1 QUINAZOLINE DERIVATIVE, SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT 한국화학연구원 2025-05-15 WO disclosed