Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL727543 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL18812859 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL18812824 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL1535436 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| Lithium Ion SCHEMBL5014706 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL11810943 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL9409022 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL847834 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL8169973 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E | |
| SCHEMBL1008471 | 0.96 | WDR5 (0.48) | WDR5LDHAALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637924-B1 | Image forming method using photothermographic material | FUJIFILM CORP (JP) | 2010-07-21 | — | — | EP | disclosed |
| US-7442495-B2 | Photothermographic material | FUJIFILM CORPORATION (JP) | 2008-10-28 | — | — | US | disclosed |
| US-7416838-B2 | Photothermographic material | FUJIFILM CORPORATION (JP) | 2008-08-26 | — | — | US | disclosed |
| US-20070207417-A1 | Photothermographic material | FUJIFILM CORPORATION | 2007-09-06 | — | — | US | disclosed |
| US-7232652-B2 | Photothermographic material and image forming method | FUJIFILM CORPORATION (JP) | 2007-06-19 | — | — | US | disclosed |
| US-20060160039-A1 | Photothermographic material | FUJIFILM CORPORATION (JP) | 2006-07-20 | — | — | US | disclosed |
| US-20060127826-A1 | Photothermographic material and image forming method | FUJI PHOTO FILM CO., LTD. | 2006-06-15 | — | — | US | disclosed |
| EP-1637924-A2 | Image forming method using photothermographic material | FUJI PHOTO FILM CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
| US-20060057508-A1 | Image forming method using photothermographic material | FUJIFILM CORPORATION (JP) | 2006-03-16 | — | — | US | disclosed |