SCHEMBL31483044

SCHEMBL31483044

COc1cc(-c2ccc3nc(NC(=O)NCCOc4cccnc4)[nH]c3c2)cnc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 14/20 1.00
PIK3CA P42336 10/20 1.00
PIK3CD O00329 10/20 1.00
ABL1 P00519 5/20 0.57
PIK3CB P42338 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483025 0.93 PIK3CA (0.86) PIK3CGPIK3CAPIK3CDABL1
SCHEMBL31483012 0.77 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL31483064 0.77 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL12992024 0.76 PIK3CG (0.61) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL31483034 0.73 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL31483028 0.71 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL31483072 0.70 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL14097413 0.70 ABL1 (0.73) ABL1
SCHEMBL31483020 0.70 PIK3CG (1.00) PIK3CGPIK3CAPIK3CDPIK3CB
SCHEMBL14097546 0.70 ABL1 (0.72) PIK3CGPIK3CAPIK3CDABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed