SCHEMBL31483025

SCHEMBL31483025

COc1cc(-c2ccc3nc(NC(=O)NCCOc4ccccc4)[nH]c3c2)cnc1OC

nearest known ligand 0.86

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 8/20 0.86
PIK3CG P48736 8/20 0.86
PIK3CD O00329 5/20 0.86
ABL1 P00519 9/20 0.55
MET P08581 1/20 0.49
CDK9 P50750 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483044 0.93 PIK3CG (1.00) PIK3CAPIK3CGPIK3CDABL1
SCHEMBL31483007 0.72 PIK3CA (0.88) PIK3CAPIK3CGPIK3CD
SCHEMBL31483012 0.69 PIK3CG (1.00) PIK3CAPIK3CGPIK3CD
SCHEMBL31483064 0.69 PIK3CG (1.00) PIK3CAPIK3CGPIK3CD
SCHEMBL31483041 0.69 PIK3CA (0.48) PIK3CAPIK3CGPIK3CD
SCHEMBL5037716 0.68 MET (0.61) PIK3CAPIK3CGPIK3CDABL1MET
SCHEMBL12992024 0.68 PIK3CG (0.61) PIK3CAPIK3CGPIK3CD
SCHEMBL10046907 0.67 PIK3CD (0.51) PIK3CAPIK3CGPIK3CDABL1
SCHEMBL12991728 0.67 PIK3CG (0.51) PIK3CAPIK3CGPIK3CD
SCHEMBL31483034 0.67 PIK3CG (1.00) PIK3CAPIK3CGPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed