SCHEMBL31484342

SCHEMBL31484342

FC(F)(F)c1ccc(C2CNC2)cn1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.46
KCNH2 Q12809 2/20 0.43
HDAC4 P56524 1/20 0.40
SLC6A3 Q01959 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
HRH3 Q9Y5N1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20757589 1.00 TRPV4 (0.46) TRPV4KCNH2HDAC4SLC6A3TAAR1
SCHEMBL15650246 0.85 HTR2A (0.49)
SCHEMBL25145866 0.83 HTR2C (0.57) TRPV4KCNH2HRH3
SCHEMBL25261460 0.82 CHRNA7 (0.34) KCNH2
SCHEMBL29496984 0.82 CHRNA7 (0.34) KCNH2
SCHEMBL25920490 0.80 HRH3 (0.47) TRPV4HDAC4HRH3
SCHEMBL25145865 0.79 TRPV4 (0.40) TRPV4KCNH2HDAC4SLC6A3TAAR1
SCHEMBL25647431 0.79 HTT (0.50) TRPV4HDAC4HRH3
SCHEMBL28935850 0.79 TRPV4 (0.46) TRPV4KCNH2HDAC4HRH3
SCHEMBL25299062 0.78 SLC6A2 (0.47) SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119630649-A Nitrogen-containing saturated heterocyclic derivative 住友制药株式会社 2025-03-14 CN disclosed