SCHEMBL31485310

SCHEMBL31485310

CC(C)(C)OC(=O)Nc1cnc2c(N3CCC(F)(F)CC3)c(F)c(NC(=O)c3ccc(NS(=O)(=O)CCO)cc3N3CCC4(CC3)CC4)cc2c1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31373464 0.89 KIF18A (0.72) KIF18A
SCHEMBL26650809 0.89 KIF18A (0.72) KIF18A
SCHEMBL26650710 0.88 KIF18A (0.68) KIF18A
SCHEMBL30748567 0.88 KIF18A (0.68) KIF18A
SCHEMBL31485402 0.87 KIF18A (0.65) KIF18A
SCHEMBL31485256 0.87 KIF18A (0.46) KIF18A
SCHEMBL30748590 0.85 KIF18A (0.71) KIF18A
SCHEMBL26650856 0.84 KIF18A (0.76) KIF18A
SCHEMBL31485368 0.84 KIF18A (0.76) KIF18A
SCHEMBL31485296 0.83 KIF18A (0.71) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4524135-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2025-03-19 — — EP disclosed
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