SCHEMBL31489008

SCHEMBL31489008

COC(=O)C(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccc(F)cc4C3)cc2)CC1

nearest known ligand 0.71

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 19/20 0.71
NPC1 O15118 1/20 0.53
MAPT P10636 1/20 0.53
RAB9A P51151 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31488830 0.90 NAMPT (0.67) NAMPTNPC1MAPTRAB9A
SCHEMBL31488949 0.89 NAMPT (0.74) NAMPTNPC1MAPTRAB9A
SCHEMBL31488893 0.87 NAMPT (0.70) NAMPTNPC1MAPTRAB9A
SCHEMBL31489036 0.85 NAMPT (0.58) NAMPTNPC1MAPTRAB9A
SCHEMBL31488852 0.85 NAMPT (0.63) NAMPT
SCHEMBL31488847 0.85 NAMPT (0.69) NAMPTNPC1MAPTRAB9A
SCHEMBL31488912 0.84 NAMPT (0.69) NAMPTNPC1MAPTRAB9A
SCHEMBL31488924 0.84 NAMPT (0.78) NAMPT
SCHEMBL31488887 0.83 NAMPT (0.51) NAMPTNPC1MAPTRAB9A
SCHEMBL31489043 0.81 NAMPT (0.84) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072437-A1 HETEROARYL COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS ALPHINA THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed