SCHEMBL31489462

SCHEMBL31489462

CC(c1ccncc1)n1cc(-c2cccc(Br)c2F)cn1

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 16/20 0.49
BRD4 O60885 7/20 0.39
PDK2 Q15119 1/20 0.36
PDK4 Q16654 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489202 0.89 CREBBP (0.46) CREBBPBRD4PDK2
SCHEMBL31489519 0.89 CREBBP (0.46) CREBBPBRD4PDK2
SCHEMBL31489263 0.74 CREBBP (0.46) CREBBPBRD4
SCHEMBL31489746 0.74 CYP17A1 (0.38) CREBBPPDK2
SCHEMBL31489590 0.74 CYP17A1 (0.38) CREBBPPDK2
SCHEMBL31489182 0.73 PDK2 (0.36) CREBBPPDK2PDK4
SCHEMBL31489229 0.73 PDK2 (0.36) CREBBPPDK2PDK4
SCHEMBL31489843 0.71 CREBBP (0.43) CREBBPBRD4PDK2
SCHEMBL21887567 0.67 PDK2 (0.49) CREBBPBRD4PDK2PDK4
SCHEMBL31489479 0.67 CREBBP (0.52) CREBBPBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed