SCHEMBL31489751

SCHEMBL31489751

CC(c1ccc(OC(F)(F)F)cc1)n1cc(-c2ccc(F)c(-c3ccn4nc(N)nc4c3)n2)cn1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 2/20 0.35
SCN5A Q14524 3/20 0.35
FGFR2 P21802 3/20 0.35
FGFR3 P22607 3/20 0.35
PIK3CG P48736 8/20 0.34
PIK3CD O00329 7/20 0.34
PIK3CA P42336 3/20 0.34
FGFR1 P11362 1/20 0.34
RIPK1 Q13546 1/20 0.33
ABL1 P00519 1/20 0.33
TRPV3 Q8NET8 1/20 0.33
GCGR P47871 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489149 1.00 CREBBP (0.35) CREBBPSCN5AFGFR2FGFR3PIK3CG
SCHEMBL31489703 0.89 PIK3CG (0.36) CREBBPFGFR2FGFR3PIK3CGPIK3CD
SCHEMBL31489545 0.88 SCN5A (0.35) CREBBPSCN5AFGFR2FGFR3PIK3CG
SCHEMBL31489281 0.86 PIK3CG (0.36) CREBBPFGFR2FGFR3PIK3CGPIK3CD
SCHEMBL31489471 0.81 PIK3CG (0.38) FGFR2FGFR3PIK3CGPIK3CDPIK3CA
SCHEMBL31489455 0.81 PIK3CG (0.35) CREBBPFGFR2FGFR3PIK3CGPIK3CD
SCHEMBL31489386 0.81 PIK3CG (0.35) FGFR2FGFR3PIK3CGPIK3CDPIK3CA
SCHEMBL31489539 0.81 PIK3CG (0.34) PIK3CGPIK3CDPIK3CARIPK1
SCHEMBL31489516 0.81 PIK3CG (0.35) FGFR2FGFR3PIK3CGPIK3CDPIK3CA
SCHEMBL31489618 0.80 PIK3CG (0.39) CREBBPPIK3CGPIK3CDPIK3CARIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed