SCHEMBL31489386

SCHEMBL31489386

CC(C)[C@H](c1ccc(F)cc1)n1cc(-c2ccc(F)c(-c3ccn4nc(N)nc4c3)n2)cn1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 14/20 0.35
PIK3CD O00329 12/20 0.35
RIPK1 Q13546 2/20 0.35
PIK3CA P42336 4/20 0.34
FGFR1 P11362 2/20 0.33
FGFR2 P21802 2/20 0.33
FGFR3 P22607 2/20 0.33
NTRK1 P04629 1/20 0.33
MAPK1 P28482 1/20 0.32
PAK4 O96013 1/20 0.32
JAK1 P23458 1/20 0.32
PIK3CB P42338 1/20 0.32
CSNK1A1 P48729 1/20 0.32
AAK1 Q2M2I8 1/20 0.32
PIP4K2C Q8TBX8 1/20 0.32
CSNK1G1 Q9HCP0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489516 1.00 PIK3CG (0.35) PIK3CGPIK3CDRIPK1PIK3CAFGFR1
SCHEMBL31489703 0.91 PIK3CG (0.36) PIK3CGPIK3CDRIPK1PIK3CAFGFR1
SCHEMBL31489404 0.88 RIPK1 (0.40) PIK3CGPIK3CDRIPK1PIK3CAPAK4
SCHEMBL31489441 0.88 RIPK1 (0.40) PIK3CGPIK3CDRIPK1PIK3CAPAK4
SCHEMBL31489281 0.88 PIK3CG (0.36) PIK3CGPIK3CDRIPK1PIK3CAFGFR1
SCHEMBL31489317 0.86 PIK3CG (0.41) PIK3CGPIK3CDRIPK1PIK3CAPAK4
SCHEMBL31489702 0.86 NTRK1 (0.33) PIK3CGPIK3CDPIK3CANTRK1
SCHEMBL31489494 0.86 NTRK1 (0.33) PIK3CGPIK3CDPIK3CANTRK1
SCHEMBL31489471 0.86 PIK3CG (0.38) PIK3CGPIK3CDRIPK1PIK3CAFGFR1
SCHEMBL31489539 0.86 PIK3CG (0.34) PIK3CGPIK3CDRIPK1PIK3CAPAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed