Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL20984924 | 0.94 | KMT2A (0.52) | KMT2AHTTLMNARAB9AMEN1 | |
| SCHEMBL29573356 | 0.89 | — | — | |
| SCHEMBL7351 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL597675 | 0.86 | L3MBTL1 (0.50) | KMT2AHTTLMNARAB9AMEN1 | |
| Bromide SCHEMBL20984641 | 0.86 | L3MBTL1 (0.50) | KMT2AHTTLMNARAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL30267828 | 0.86 | L3MBTL1 (0.50) | KMT2AHTTLMNARAB9AMEN1 | |
| Sulfuric Acid SCHEMBL20984747 | 0.85 | CA1 (0.53) | KMT2AHTTLMNARAB9AMEN1 | |
| Phosphoric Acid SCHEMBL20984859 | 0.85 | L3MBTL1 (0.47) | KMT2AHTTLMNARAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL838681 | 0.84 | L3MBTL1 (0.48) | KMT2AHTTLMNARAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL6780328 | 0.84 | L3MBTL1 (0.48) | KMT2AHTTLMNARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025046420-A1 | COMPOUND TARGETING EGR-1 AND USE THEREOF FOR TREATMENT OF ATOPIC DERMATITIS | 주식회사 아제라메디 | 2025-03-06 | — | — | WO | disclosed |