Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 7/20 | 0.41 |
| ▸ | F3 | P13726 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4243042 | 0.99 | HTR1A (0.52) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| SCHEMBL301711 | 0.90 | CHRM2 (0.62) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| SCHEMBL3154423 | 0.90 | CHRM2 (0.62) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4246589 | 0.89 | CHRM2 (0.61) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4246608 | 0.89 | CHRM2 (0.61) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4244379 | 0.89 | CHRM2 (0.61) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| SCHEMBL3438788 | 0.87 | HTR1A (0.56) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| SCHEMBL3146088 | 0.86 | CHRM2 (0.58) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| SCHEMBL17120954 | 0.85 | DRD3 (0.57) | HTR1ACHRM2SLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4247812 | 0.85 | CHRM2 (0.57) | HTR1ACHRM2SLC6A4DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |