Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 16/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159265 | 0.92 | NR1H4 (0.54) | NR1H4PPARD | |
| SCHEMBL3150227 | 0.82 | NR1H4 (0.59) | NR1H4PPARG | |
| SCHEMBL498139 | 0.81 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL497577 | 0.77 | NR1H4 (0.60) | NR1H4 | |
| SCHEMBL497776 | 0.76 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL498015 | 0.75 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL497662 | 0.75 | NR1H4 (0.56) | NR1H4 | |
| SCHEMBL498491 | 0.75 | NR1H4 (0.64) | NR1H4 | |
| SCHEMBL498129 | 0.75 | NR1H4 (0.68) | NR1H4 | |
| SCHEMBL498302 | 0.74 | NR1H4 (0.60) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |