Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.57 |
| ▸ | HRH1 | P35367 | 7/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024144 | 0.91 | HRH1 (0.55) | HTR6HRH1EGFRIGF1RFLT4 | |
| Hydrochloric Acid SCHEMBL2025854 | 0.90 | HTR6 (0.54) | HTR6HRH1EGFRIGF1RFLT4 | |
| Hydrochloric Acid SCHEMBL2024394 | 0.90 | HTR6 (0.54) | HTR6HRH1EGFRIGF1RFLT4 | |
| SCHEMBL3144810 | 0.85 | HTR6 (0.42) | HTR6HRH1EGFRIGF1RFLT4 | |
| SCHEMBL14218042 | 0.83 | HRH1 (0.60) | HTR6HRH1SCARB1 | |
| SCHEMBL13478810 | 0.83 | HTR6 (0.60) | HTR6HRH1SCARB1 | |
| SCHEMBL19015842 | 0.83 | HRH1 (0.55) | HTR6HRH1SCARB1CNR1 | |
| SCHEMBL1878809 | 0.83 | HRH1 (0.49) | HTR6HRH1EGFRIGF1RFLT4 | |
| SCHEMBL12637193 | 0.83 | HRH1 (0.49) | HTR6HRH1EGFRIGF1RFLT4 | |
| Hydrochloric Acid SCHEMBL17592674 | 0.82 | HTR6 (0.54) | HTR6HRH1EGFRIGF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-1902026-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002181-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |