Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150514 | 0.87 | HRH3 (0.49) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL3158474 | 0.85 | HRH3 (0.52) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL3158460 | 0.85 | HRH3 (0.52) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL12376851 | 0.83 | GCGR (0.52) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL4920804 | 0.83 | HRH3 (0.72) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL3150507 | 0.83 | HRH3 (0.48) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL3150496 | 0.83 | HRH3 (0.48) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL2284285 | 0.82 | HRH3 (0.60) | HRH3HRH1S1PR1S1PR3MAOB | |
| SCHEMBL13438274 | 0.68 | HRH3 (0.56) | HRH3HRH1MAOBKCNH2 | |
| SCHEMBL991736 | 0.67 | HRH3 (1.00) | HRH3HRH1S1PR1MAOBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157087-A1 | 3-(4-{[4-(4-{[3-(3,3-DIMETHYL-1-PIPERIDINYL)PROPYL]OXY}PHENYL)-1-PIPERIDINYL]CARBONYL}-1-NAPHTHALENYL)PROPANOIC OR PROPENOIC ACID AS H1 AND H3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2010-02-24 | — | — | EP | disclosed |
| EP-1963307-B1 | 3- (4- { [4-(4-{ [3-(3, 3-DIMETHYL-1-PIPERIDINYL) PROPYL[0XY] PHENYL) -1-PIPERIDINYL CARBONYL }-1-NAPHTHALENYL) PROPANOIC OR PROPENOIC ACID AS H1 AND H3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC DISORDERS | GLAXO GROUP LTD (GB) | 2009-11-25 | — | — | EP | disclosed |