Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3158460 | 1.00 | HRH3 (0.52) | HRH3HRH1MAOBKCNH2MEN1 | |
| SCHEMBL3150507 | 0.91 | HRH3 (0.48) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL3150496 | 0.91 | HRH3 (0.48) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL3150514 | 0.87 | HRH3 (0.49) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL3150503 | 0.85 | HRH3 (0.51) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL12376851 | 0.84 | GCGR (0.52) | HRH3HRH1MAOBKCNH2MEN1 | |
| SCHEMBL4920804 | 0.84 | HRH3 (0.72) | HRH3HRH1MAOBKCNH2MEN1 | |
| SCHEMBL2284285 | 0.80 | HRH3 (0.60) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL991736 | 0.68 | HRH3 (1.00) | HRH3HRH1MAOBKCNH2S1PR1 | |
| SCHEMBL13437974 | 0.68 | HRH3 (0.56) | HRH3HRH1MAOBKCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157087-A1 | 3-(4-{[4-(4-{[3-(3,3-DIMETHYL-1-PIPERIDINYL)PROPYL]OXY}PHENYL)-1-PIPERIDINYL]CARBONYL}-1-NAPHTHALENYL)PROPANOIC OR PROPENOIC ACID AS H1 AND H3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2010-02-24 | — | — | EP | disclosed |
| EP-1963307-B1 | 3- (4- { [4-(4-{ [3-(3, 3-DIMETHYL-1-PIPERIDINYL) PROPYL[0XY] PHENYL) -1-PIPERIDINYL CARBONYL }-1-NAPHTHALENYL) PROPANOIC OR PROPENOIC ACID AS H1 AND H3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC DISORDERS | GLAXO GROUP LTD (GB) | 2009-11-25 | — | — | EP | disclosed |