Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25286651 | 1.00 | CES1 (0.45) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL3151110 | 1.00 | CES1 (0.45) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL6450713 | 1.00 | CES1 (0.45) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL3346621 | 0.95 | PDE4A (0.50) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL9095034 | 0.95 | PDE4A (0.50) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL25197599 | 0.95 | PDE4A (0.50) | CES1CES2AKR1B1PDE4AMEN1 | |
| SCHEMBL10351577 | 0.95 | PDE4A (0.50) | CES1CES2AKR1B1PDE4AMEN1 | |
| Ammonia Solution, Strong SCHEMBL27687216 | 0.93 | PDE4A (0.48) | CES1CES2AKR1B1PDE4AMEN1 | |
| Water SCHEMBL28217782 | 0.93 | PDE4A (0.48) | CES1CES2AKR1B1PDE4AMEN1 | |
| Acetic Acid SCHEMBL31555913 | 0.90 | PDE4A (0.46) | CES1CES2AKR1B1PDE4AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044102-A1 | New Method for Preparing Isofagomine and Its Derivatives | AMICUS THERAPEUTICS INC (US) | 2017-02-16 | — | — | US | disclosed |
| US-9481700-B2 | Method for preparing isofagomine and its derivatives | AMICUS THERAPEUTICS, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20140005372-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | AMICUS THERAPEUTICS INC (US) | 2014-01-02 | — | — | US | disclosed |
| US-8487110-B2 | Method for preparing isofagomine and its derivatives | AMICUS THERAPEUTICS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20100160638-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | AMICUS THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| EP-2152265-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | Amicus Therapeutics, Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008144773-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | AMICUS THERAPEUTICS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005372-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | ALDOA, FBP1, GALE | CES1 3652/4885CES2 1493/4885AKR1B1 1246/4885 |
| US-20100160638-A1 | NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES | ALDOA, FBP1, GALE | CES1 3652/4885CES2 1493/4885AKR1B1 1246/4885 |
| US-20170044102-A1 | New Method for Preparing Isofagomine and Its Derivatives | ALDOA, FBP1, GALE | CES1 3652/4885CES2 1493/4885AKR1B1 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.