Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | RHEB | Q15382 | 1/20 | 0.47 |
| ▸ | ATP4A | P20648 | 2/20 | 0.47 |
| ▸ | ATP4B | P51164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386139 | 0.86 | STAT3 (0.51) | HTTSMN1; SMN2STAT3RHEBATP4A | |
| SCHEMBL17494990 | 0.86 | RHEB (0.46) | HTTSMN1; SMN2STAT3RHEBATP4A | |
| SCHEMBL26608491 | 0.85 | NPC1 (0.44) | HTTSMN1; SMN2RHEBL3MBTL1MAPT | |
| SCHEMBL26601861 | 0.85 | PTGDR2 (0.49) | HTTSMN1; SMN2STAT3L3MBTL1MAPT | |
| SCHEMBL31517925 | 0.84 | HTT (0.47) | HTTSMN1; SMN2STAT3L3MBTL1MAPT | |
| SCHEMBL26601750 | 0.83 | PTGER1 (0.45) | HTTSMN1; SMN2STAT3MCL1PLAU | |
| SCHEMBL30624528 | 0.83 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2STAT3RHEBATP4A | |
| SCHEMBL26601670 | 0.83 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2STAT3RHEBATP4A | |
| SCHEMBL26601758 | 0.83 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2STAT3ATP4AATP4B | |
| SCHEMBL4781292 | 0.82 | HTT (0.54) | HTTSMN1; SMN2STAT3RHEBATP4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025090480-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-05-01 | — | — | WO | disclosed |