Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 1/20 | 0.40 |
| ▸ | ATP4B | P51164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26601809 | 0.86 | RHEB (0.47) | RHEBPLAUSMN1; SMN2STAT3HTT | |
| SCHEMBL31517865 | 0.86 | HTT (0.49) | RHEBPLAUSMN1; SMN2STAT3HTT | |
| SCHEMBL30666902 | 0.79 | POLB (0.44) | RHEBPLAUSMN1; SMN2NPC1NFKB1 | |
| SCHEMBL17494984 | 0.78 | SMN1; SMN2 (0.39) | RHEBPLAUPRMT5SMN1; SMN2STAT3 | |
| SCHEMBL17495074 | 0.75 | RAB9A (0.52) | SMN1; SMN2STAT3HTTPTGER1NPC1 | |
| SCHEMBL30403655 | 0.75 | SQOR (0.49) | SMN1; SMN2STAT3HTTNPC1RAB9A | |
| SCHEMBL30522860 | 0.74 | MAPT (0.46) | PRMT5SMN1; SMN2STAT3HTTPTGER1 | |
| SCHEMBL28848218 | 0.74 | MAPT (0.46) | PRMT5SMN1; SMN2STAT3HTTPTGER1 | |
| SCHEMBL26601861 | 0.74 | PTGDR2 (0.49) | SMN1; SMN2STAT3HTTPTGER1MCL1 | |
| SCHEMBL17536018 | 0.74 | S1PR4 (0.52) | RHEBSMN1; SMN2PTGER1NPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025933-A2 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2016025932-A1 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |