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SCHEMBL3152256

SCHEMBL3152256

CN(c1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 18/20 0.61
▸ CNR1 P21554 5/20 0.51
▸ NPC1 O15118 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ ULK1 O75385 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL714681 0.79 KDM4E (0.46) NPC1MAPTRAB9AKMT2ASMN1; SMN2
SCHEMBL3152268 0.79 CNR2 (0.70) CNR2CNR1MAPT
SCHEMBL3039967 0.76 CNR2 (1.00) CNR2CNR1
SCHEMBL13456267 0.74 CNR2 (0.72) CNR2CNR1
SCHEMBL13456183 0.73 CNR2 (0.73) CNR2CNR1
SCHEMBL3208969 0.73 CNR2 (0.69) CNR2CNR1
SCHEMBL3047370 0.71 CNR2 (1.00) CNR2CNR1
SCHEMBL3034472 0.69 CNR2 (1.00) CNR2CNR1KMT2A
SCHEMBL3038915 0.69 CNR2 (0.70) CNR2CNR1
SCHEMBL3037152 0.69 CNR2 (1.00) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2139852-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS Pharmos Corporation (US) 2010-01-06 — — EP disclosed
WO-2008075353-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION (US) 2008-06-26 — — WO disclosed