SCHEMBL3208969

SCHEMBL3208969

NS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F

nearest known ligand 0.69

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 19/20 0.69
CNR1 P21554 5/20 0.64
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13456184 0.90 CNR2 (0.57) CNR2CNR1
SCHEMBL13456183 0.85 CNR2 (0.73) CNR2CNR1
SCHEMBL3037152 0.82 CNR2 (1.00) CNR2CNR1
SCHEMBL3923293 0.80 CA12 (0.53) CNR2CA1CA2CA7CA9
SCHEMBL3036380 0.79 CNR2 (1.00) CNR2CNR1
SCHEMBL3047370 0.79 CNR2 (1.00) CNR2CNR1
SCHEMBL3046020 0.79 CNR2 (1.00) CNR2CNR1
SCHEMBL3034466 0.79 CNR2 (1.00) CNR2CNR1
SCHEMBL3042365 0.79 CNR2 (1.00) CNR2CNR1
SCHEMBL13456402 0.79 CNR2 (0.60) CNR2CNR1CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9422235-B2 Sulfonamide derivatives with therapeutic indications PHARMOS CORPORATION (US) 2016-08-23 US claimed
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION 2010-03-04 US claimed
US-9422235-B2 Sulfonamide derivatives with therapeutic indications PHARMOS CORPORATION (US) 2016-08-23 US disclosed
US-9422235-B2 Sulfonamide derivatives with therapeutic indications PHARMOS CORPORATION (US) 2016-08-23 US disclosed
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION 2010-03-04 US disclosed
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS PHARMOS CORPORATION 2010-03-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056528-A1 SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS SULT2A1, STS, SULT1A1 CNR2 41/4885CNR1 207/4885CA1 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.