Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315232 | 1.00 | PDE3B (0.41) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL315231 | 1.00 | PDE3B (0.41) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL11658276 | 0.95 | PDE3B (0.40) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL315113 | 0.81 | PDE3B (0.48) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL315114 | 0.81 | PDE3B (0.48) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL315112 | 0.81 | PDE3B (0.48) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL11657761 | 0.79 | CHRM1 (0.42) | HTR2CHTR2AHTR2BCHRM1ALDH1A1 | |
| SCHEMBL13729633 | 0.79 | MAPKAPK2 (0.37) | HTR2CMAPKAPK2HTR2AHTR2BCHRM1 | |
| SCHEMBL11654866 | 0.77 | PDE3B (0.47) | PDE3BPDE3AHTR2CMAPKAPK2HTR2A | |
| SCHEMBL12654554 | 0.77 | PARP1 (0.36) | ALDH1A1HPGDGAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306042-A1 | Triazole Derivatives | TGFBR1, TGFBR2, SMAD3 | PDE3B 1435/4885PDE3A 1244/4885HTR2C 3617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.