Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.45 |
| ▸ | DRD4 | P21917 | 6/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27193665 | 1.00 | PDE1B (0.45) | PDE1BDRD4GRM4PDE1CPDE1A | |
| SCHEMBL27193403 | 1.00 | PDE1B (0.45) | PDE1BDRD4GRM4PDE1CPDE1A | |
| SCHEMBL27193455 | 0.81 | PDE1B (0.47) | PDE1BPDE1CPDE1ACNR1CNR2 | |
| SCHEMBL1592906 | 0.80 | PDE1B (0.55) | PDE1BPDE1CPDE1ACNR1CNR2 | |
| SCHEMBL27193571 | 0.80 | PDE1B (0.46) | PDE1BPDE1CPDE1ACNR1CNR2 | |
| SCHEMBL16536339 | 0.80 | PDE1B (0.51) | PDE1BCNR1CNR2 | |
| SCHEMBL1592961 | 0.80 | PDE1B (0.53) | PDE1BPDE1CPDE1ACNR1CNR2 | |
| SCHEMBL31533705 | 0.78 | GRM4 (0.37) | GRM4GPR84 | |
| SCHEMBL27193526 | 0.78 | GRM4 (0.37) | GRM4GPR84 | |
| SCHEMBL27193702 | 0.78 | GRM4 (0.37) | GRM4GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119654314-A | Heterocyclic amide and urea compounds as JAK2 inhibitors | 艾捷斯治疗公司 | 2025-03-18 | — | — | CN | disclosed |