Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.55 |
| ▸ | ACACA | Q13085 | 2/20 | 0.55 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112739 | 0.83 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2HTTNOTUM | |
| SCHEMBL3117537 | 0.82 | NOTUM (0.65) | NPC1RAB9ASMN1; SMN2HTTNOTUM | |
| SCHEMBL91541 | 0.81 | NOTUM (0.68) | ACACBACACANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28668539 | 0.81 | RAB9A (0.52) | ACACBACACANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27548991 | 0.81 | PPARA (0.59) | NPC1RAB9ASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL27454679 | 0.81 | PPARA (0.59) | NPC1RAB9ASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL315338 | 0.80 | ACACB (0.47) | ACACBACACAAPOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL10053485 | 0.80 | SMN1; SMN2 (0.63) | ACACBACACANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12525780 | 0.80 | MAPT (0.61) | ACACBACACANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3119605 | 0.79 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2HTTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093400-B2 | Compounds useful in therapy | PFIZER INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100317652-A1 | Compounds Useful In Therapy | PFIZER INC | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317652-A1 | Compounds Useful In Therapy | AVPR1A, AVPR1B, AVPR2 | ACACB 4425/4885ACACA 3583/4885APOBEC3A 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.