Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18053855 | 1.00 | CDK1 (0.42) | CDK1CCNB1MGMTCCNA2CDK2 | |
| SCHEMBL1480240 | 0.76 | HPGD (0.44) | HPGDALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL3642504 | 0.73 | NPC1 (0.41) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL10158674 | 0.73 | GPR174 (0.41) | GPR174MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL27703269 | 0.71 | KDM4E (0.43) | DRD1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL20587874 | 0.71 | MAPT (0.42) | CDK1CCNB1MGMTCCNA2CDK2 | |
| SCHEMBL760839 | 0.71 | — | — | |
| SCHEMBL30601875 | 0.71 | — | — | |
| SCHEMBL18785800 | 0.70 | MAPT (0.38) | GPR174MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL19686190 | 0.69 | TSHR (0.48) | GPR174HPGDALDH1A1CCR8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |