Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149867 | 0.89 | MAPK14 (0.38) | PI4KAPI4K2BPI4K2API4KBMAPK14 | |
| SCHEMBL3154106 | 0.84 | MAPK14 (0.49) | HTR7MAPK14MAPK11TTK | |
| SCHEMBL3146393 | 0.76 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL3145456 | 0.75 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL3149778 | 0.75 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL3148658 | 0.74 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL3145425 | 0.73 | MAPK14 (0.53) | MAPK14MAPK11 | |
| SCHEMBL3138749 | 0.73 | MAPK14 (0.47) | MAPK14TTK | |
| SCHEMBL3146079 | 0.73 | MAPK14 (0.51) | MAPK14MAPK11 | |
| SCHEMBL28762590 | 0.72 | MAPK14 (0.46) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699800-B1 | BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-02-10 | — | — | EP | disclosed |