Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | BLM | P54132 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | FAAH | O00519 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | RECQL | P46063 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | APEX1 | P27695 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.69 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928628 | 0.95 | MEN1 (0.69) | CNR1ALDH1A1MEN1BLMKMT2A | |
| SCHEMBL13400832 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL6891974 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL25712483 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL3492921 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL2680708 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL22190346 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL15061596 | 0.89 | HSP90AA1 (0.77) | MEN1BLMKMT2AFAAHMAPT | |
| Potassium SCHEMBL32681948 | 0.87 | HSP90AA1 (0.74) | MEN1BLMKMT2AFAAHMAPT | |
| SCHEMBL3634730 | 0.86 | CNR1 (0.71) | CNR1ALDH1A1MEN1BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511737-B1 | ARYLOXIMES | MERCK PATENT GMBH (DE) | 2010-02-17 | — | — | EP | disclosed |
| EP-1509506-B1 | PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-7563790-B2 | Pyridazine derivatives | MERCK PATENT GMBH (DE) | 2009-07-21 | — | — | US | disclosed |
| US-7470687-B2 | Aryl oximes | MERCK PATENT GMBH (DE) | 2008-12-30 | — | — | US | disclosed |
| US-20060270681-A1 | Pyridazine derivatives | EGGENWEILER HANS-MICHAEL | 2006-11-30 | — | — | US | disclosed |
| US-7135471-B2 | Aryl oximes | MERCK PATENT GMBH (DE) | 2006-11-14 | — | — | US | disclosed |
| US-7129241-B2 | Pyridazine derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2006-10-31 | — | — | US | disclosed |
| US-20060205708-A1 | Aryl oximes | EGGENWEILER HANS-MICHAEL | 2006-09-14 | — | — | US | disclosed |
| US-20050209240-A1 | Aryl oximes | MERCK PATENT GMBH (DE) | 2005-09-22 | — | — | US | disclosed |
| CN-1659147-A | Pyridazine derivatives | MERCK PATENT GMBH (DE) | 2005-08-24 | — | — | CN | disclosed |
| WO-1990008545-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | disclosed |
| EP-0374602-A1 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4761403-A | QUINOLONE DERIVATIVES | ABBOTT LABORATORIES (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0240859-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1987-10-14 | — | — | EP | disclosed |
| US-4623661-A | HYDROXAMIC ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0199152-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-10-29 | — | — | EP | disclosed |
| EP-0199153-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-10-29 | — | — | EP | disclosed |
| EP-0199151-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4608390-A | ANTIINFLAMMORY, ANTIALLERGENS, ASTHMA, PSORIASIS, ARTHRITIS | ABBOTT LABORATORIES (US) | 1986-08-26 | — | — | US | disclosed |
| US-4605669-A | Lipoxygenase inhibiting naphthohydroxamic acids | ABBOTT LABORATORIES (US) | 1986-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205708-A1 | Aryl oximes | PDE3B, CHRM1, MSR1 | CNR1 701/4885ALDH1A1 1110/4885MEN1 3069/4885 |
| US-20060270681-A1 | Pyridazine derivatives | PDE4A, PDE5A, PDE12 | CNR1 1519/4885ALDH1A1 1898/4885MEN1 2466/4885 |
| US-20050209240-A1 | Aryl oximes | PDE3B, CHRM1, MSR1 | CNR1 701/4885ALDH1A1 1110/4885MEN1 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.