Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | CNR1 | P21554 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | F7 | P08709 | 3/20 | 0.67 |
| ▸ | F3 | P13726 | 3/20 | 0.67 |
| ▸ | PPARG | P37231 | 2/20 | 0.67 |
| ▸ | PPARD | Q03181 | 2/20 | 0.67 |
| ▸ | PPARA | Q07869 | 2/20 | 0.67 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154754 | 0.95 | CNR1 (0.71) | MEN1KMT2AALDH1A1HPGDCNR1 | |
| SCHEMBL6891974 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL15061596 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL22190346 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL13400832 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL25712483 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL2680708 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL3492921 | 0.95 | HSP90AA1 (0.77) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| Potassium SCHEMBL32681948 | 0.93 | HSP90AA1 (0.74) | MEN1KMT2AHSP90AA1TDP1MAPT | |
| SCHEMBL23280891 | 0.86 | MEN1 (0.69) | MEN1KMT2AALDH1A1HPGDCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239807-A1 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-27 | — | — | US | claimed |
| US-7956062-B2 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | DUKE UNIVERSITY (US) | 2011-06-07 | — | — | US | disclosed |
| US-20100010019-A1 | Reactive Oxygen Generating Enzyme Inhibitor With Nitric Oxide Bioactivity and Uses Thereof | DUKE UNIVERSITY (US) | 2010-01-14 | — | — | US | disclosed |
| US-7625907-B2 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | DUKE UNIVERSITY (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1737867-A4 | REACTIVE OXYGEN GENERATING ENZYME INHIBITOR WITH NITRIC OXIDE BIOACTIVITY AND USES THEREOF | UNIV DUKE (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1737867-A1 | REACTIVE OXYGEN GENERATING ENZYME INHIBITOR WITH NITRIC OXIDE BIOACTIVITY AND USES THEREOF | Duke University (US) | 2007-01-03 | — | — | EP | disclosed |
| US-20060194820-A1 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | DUKE UNIVERSITY (US) | 2006-08-31 | — | — | US | disclosed |
| US-7067659-B2 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | DUKE UNIVERSITY (US) | 2006-06-27 | — | — | US | disclosed |
| WO-2005105806-A1 | REACTIVE OXYGEN GENERATING ENZYME INHIBITOR WITH NITRIC OXIDE BIOACTIVITY AND USES THEREOF | DUKE UNIVERSITY (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050239807-A1 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194820-A1 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | NOS1, NOS2, SOD1 | MEN1 4404/4885KMT2A 4683/4885HSP90AA1 2085/4885 |
| US-20050239807-A1 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof | NOS1, SOD1, NOS3 | MEN1 4652/4885KMT2A 4573/4885HSP90AA1 2642/4885 |
| US-20100010019-A1 | Reactive Oxygen Generating Enzyme Inhibitor With Nitric Oxide Bioactivity and Uses Thereof | NOS1, NOS2, SOD1 | MEN1 4404/4885KMT2A 4683/4885HSP90AA1 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.