Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TTPA | P49638 | 4/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747835 | 0.98 | MEN1 (0.64) | MEN1KMT2APDE4APDE3AGSTO1 | |
| Hydrochloric Acid SCHEMBL3151645 | 0.97 | MEN1 (0.62) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL8747830 | 0.85 | MEN1 (0.50) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL8377650 | 0.84 | MEN1 (0.67) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL8601254 | 0.83 | MEN1 (0.66) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL3096678 | 0.82 | MEN1 (0.65) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL13156985 | 0.82 | MEN1 (0.65) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL8484326 | 0.82 | MEN1 (0.56) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL8376060 | 0.82 | MEN1 (0.64) | MEN1KMT2APDE4APDE3AGSTO1 | |
| SCHEMBL14168733 | 0.82 | MEN1 (0.64) | MEN1KMT2APDE4APDE3AGSTO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2151846-B1 | High temperature thermal cutoff device | THERM O DISC INC (US) | 2013-10-09 | — | — | EP | disclosed |
| EP-2151846-A2 | High temperature thermal cutoff device | Therm-O-Disc Incorporated (US) | 2010-02-10 | — | — | EP | disclosed |