Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4243022 | 0.99 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3149555 | 0.89 | KMT2A (0.48) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4243020 | 0.88 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3150480 | 0.81 | DPP4 (0.51) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4250477 | 0.81 | DPP4 (0.50) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3154423 | 0.80 | CHRM2 (0.62) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL301711 | 0.80 | CHRM2 (0.62) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4244379 | 0.79 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4246589 | 0.79 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4246608 | 0.79 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |