Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4243020 | 0.99 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| SCHEMBL3155256 | 0.89 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4243022 | 0.88 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL301711 | 0.85 | CHRM2 (0.62) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| SCHEMBL3154423 | 0.85 | CHRM2 (0.62) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| Hydrochloric Acid SCHEMBL4246608 | 0.84 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| Hydrochloric Acid SCHEMBL4244379 | 0.84 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| Hydrochloric Acid SCHEMBL4246589 | 0.84 | CHRM2 (0.61) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 | |
| SCHEMBL4246922 | 0.82 | NPC1 (0.53) | KMT2ANPC1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3146088 | 0.82 | CHRM2 (0.58) | KMT2ARAB9ASMN1; SMN2NPC1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |