Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3781499 | 0.99 | CHRNB4 (0.34) | CHRNB4CHRNA3CHRNA7HTR2BPDE4D | |
| SCHEMBL3145422 | 0.83 | INPPL1 (0.43) | CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL3775585 | 0.82 | INPPL1 (0.42) | CHRNB4CHRNA3 | |
| SCHEMBL3155932 | 0.82 | DHFR (0.39) | CHRNB4CHRNA3CHRNA7KDM1A | |
| SCHEMBL3155918 | 0.81 | FGFR1 (0.33) | — | |
| SCHEMBL3141866 | 0.81 | CHRNB4 (0.37) | CHRNB4CHRNA3CHRNA7KDM1A | |
| SCHEMBL3141943 | 0.81 | GAK (0.33) | CHRNB4CHRNA3CHRNA7SIK1SIK2 | |
| Hydrochloric Acid SCHEMBL3767963 | 0.81 | DHFR (0.38) | CHRNB4CHRNA3CHRNA7KDM1A | |
| Hydrochloric Acid SCHEMBL3776498 | 0.81 | FGFR1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL3780031 | 0.80 | GAK (0.32) | CHRNB4CHRNA3CHRNA7SIK1SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |