SCHEMBL3155307

SCHEMBL3155307

NCC1(COc2cnc(Cl)c(-c3cccnc3)c2)CC1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.39
CHRNA7 P36544 1/20 0.37
THRA P10827 1/20 0.37
THRB P10828 1/20 0.37
CYP2A6 P11509 1/20 0.36
CYP17A1 P05093 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3771666 0.99 ABL1 (0.39) ABL1CHRNA7THRATHRBCYP2A6
SCHEMBL3155946 0.88 FFAR4 (0.41) CHRNA7
Hydrochloric Acid SCHEMBL3774060 0.87 FFAR4 (0.40) CHRNA7
SCHEMBL3145927 0.87 CHRNB4 (0.38) CHRNA7
SCHEMBL3150927 0.86 KDM1A (0.37) CYP17A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL3147355 0.86 CHRNB4 (0.37) CHRNA7
Hydrochloric Acid SCHEMBL3773904 0.85 KDM1A (0.36) CYP2A6CYP17A1CYP3A4CYP11B1CYP11B2
SCHEMBL3155932 0.85 DHFR (0.39) CHRNA7
SCHEMBL3154920 0.84 MAP4K4 (0.35) CHRNA7
Hydrochloric Acid SCHEMBL3767963 0.84 DHFR (0.38) CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979321-B9 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2010-02-17 EP disclosed
EP-1979321-B1 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2009-07-29 EP disclosed